In 2015, the International Panel for NMO Diagnosis (IPND) revised the diagnostic criteria for NMOSD according to anti-AQP4 antibody status with an emphasis on six locations of the lesions (spinal cord, optic nerves, area postrema, diencephalon, brainstem and cerebrum) and typical MRI features [44,45]. Here, AQP4 is linked to neuromyelitis optica.