In literature, the characteristic MRI features of NMO are reported as confluent and asymmetrical hyperintense lesions on T2-weighted and FLAIR images in typical areas where AQP4 is consistently expressed (optic nerve, periependymal regions, structures around the third and fourth ventricles and the cerebral aqueduct, spinal cord, optic chiasm, hypothalamus, subpial areas, brainstem, and area postrema) [49]. This evidence concerns the gene AQP4 and neuromyelitis optica.