DGAT2 and hyperlipidemia: Chronic and excessive lipid absorption induces hyperlipidemia, leading to lipotoxicity in peripheral lipid storage tissues such as ATs, liver, and muscles [43,44] promotes hepatic lipid accumulation accompanied with up-regulation of lipogenic gene expression including Srebf1, Pgc1b, Acc1, Acc2, Fas, Dgat1, Dgat2, and Gpat [45].