It has been shown that, among these family, FABP4 and FABP5 expressed in macrophages in addition to adipocytes play pivotal roles within the pathogenesis of diabetes mellitus (DM), as well as atherosclerosis [4,5,6,7,8,9], and significant increase of the serum levels of FABP4 and 5 were detected in patients with several cardiovascular and metabolic diseases [10,11,12,13,14,15,16,17,18,19]. Here, FABP4 is linked to metabolic disease.