Taken together with the fact that both FABP4 and FABP5 are (1) expressed within the endothelial cells in addition to adipocytes and macrophages [1], and (2) are involved in the physiological and pathophysiological conditions related to several metabolic and cardiovascular diseases [10,17], we rationally speculate that Vt-FABP4 or Vt-FABP5 may solely or, in cooperation with Vt-VEGFA, be involved in the etiology of RVDs following the inflammatory damage of retinal endothelial cells. This evidence concerns the gene FABP4 and cardiovascular disorder.