In line with these data, in a serial engraftment mouse model of Fanca+/+; Tp53−/−; Ccnd1OE; HRASG12V versus Fanca−/−; Tp53−/−; Ccnd1OE; HRASG12V, FA loss of function accelerated tumor development together with early signatures reflective of EMT, cancer stem cell transition and metastasis [163]. This evidence concerns the gene FANCA and cancer.