COPB2 and cancer: Furthermore, the receptor tyrosine kinase (RTK), c-Jun N-terminal kinase (JNK)/c-Jun signaling pathways, as well as certain microRNAs, such as miR-4461, miR-335-3p, and miR-216a-3p, have been delineated as molecular mechanisms related to the oncogenic functions of COPB2 in cancer progression [5,6,7,8,9].