Recently, according to the bioinformatical analysis of the public database, such as GSE16011, some investigators found that the expression status of the COPB2 transcript was significantly related to the recruitment of immune cells, the major histocompatibility complex (MHC); they postulated that the regulatory action of COPB2 on TIME may be a crucial molecular contributor to its clinicopathological significance in cancer progression [10]. The gene discussed is HLA-C; the disease is cancer.