In the phosphorylated pathway, the phosphorylated CagA protein with src homology phosphatase 2 (SHP2)) along with the growth factor receptor-bound protein 2 (Grb2)48 activate oncoproteins such as extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAPK), and CT10 (chicken tumor virus No. 10) regulator of the kinase (Crk) Crk/Crk-linker (Crk-L) signaling pathways, that lead to irregulated cell proliferation and the development of GC [27,29,30]. Here, CRK is linked to gastric cancer.