Twenty-nine protein biomarkers were subsequently evaluated for potential use in screening for pancreatic cancer, of those 29 biomarkers, five were found to be elevated in PDAC: carcinoembryonic antigen (CEA), hepatocyte growth factor (HGF), osteopontin (OPN), midkine, and prolactin. Here, CEACAM5 is linked to familial pancreatic carcinoma.