Analysis of the COAD TCGA cohort, including 438 human primary colon cancers with corresponding clinical data, revealed that expression above the median value of most previously reported TASC markers genes, including LOXL2, podoplanin (PDPN), FAP, FSP-1, CALD1, POSTN, IGFB7, BGN, and PLOD2, is devoid of prognostic significance. The gene discussed is PLOD2; the disease is malignant colon neoplasm.