Most importantly, the expression of genes encoding two members of the latter group, calponin-1 (CNN1) and tropomyosin beta chain isoform 2 (TPM2), significantly correlates with severe prognosis in colon cancer public databases and outperforms the expression of previously reported TASC-associated markers, consistent with a potentially higher clinical relevance. The gene discussed is CNN1; the disease is colonic neoplasm.