Amongst the AML samples with NGS data available (n = 54), we pooled the 14 RAS mutated AML with the 10 mutated TP53 mutated AML to obtain a group of 22 patients (two AML patients had both RAS and TP53 mutations); in this group of AML patients with TP53 and/or RAS mutated, response rate was lower (31% vs. 66%, Figure 3D–E and Supplementary Table S3). Here, TP53 is linked to acute myeloid leukemia.