The combination treatment with vincristine, dexamethasone, L-asparaginase, and ruxolitinib of mice engrafted with CRLF2-rearranged Ph-like ALL patient-derived xenografts decreased leukemic infiltration of various organs and prolonged time to remission, as compared to chemotherapy or ruxolitinib alone [67]. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.