CTLA4 and neoplasm: Immunotherapy reverses the tumor-expressed extracellular ligands, which subdue intrinsic immune response, with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4, sometimes known as CD152) and programmed cell death protein-1 (PD-1 or CD279) as well as ligand PD-L1 being the classical examples.