Several prognostic predictors in patients with HCC receiving sorafenib, such as the presence of hand-foot skin reaction (HFSR) [10], ALBI grade [11], early AFP response [12], progression pattern [13,14] and the PROSASH-II model [15], may also have prognostic value for regorafenib treatment. The gene discussed is AFP; the disease is hepatocellular carcinoma.