TGFB1 and cancer: Figure 8 shows the results of the immunohistochemical analysis in the hMSC/PU scaffold constructs for some key ECM molecules, such as collagen type I (Figure 8A) and fibronectin (Figure 8C), as well as a fundamental signaling molecule, TGF-β1 (Figure 8B), present in bone, which is considered to play a role in cancer progression and metastasis.