ITIH4 and cancer: However, the heatmap indicates a discrimination between PCa patients and non-cancer subjects based on two protein clusters: ITIH4*G893S (Inter-alpha-trypsin inhibitor heavy chain H4)-LMAN2*D222N (Vesicular integral-membrane protein VIP36); KLK3*C209Y (PSA)-MVB12B*T198M (Multivesicular body subunit 12B) (Figure 4B).