Then, differential protein analysis revealed 18 dysregulated proteins in PCa, with 4 proteins (p-value ≤ 0.05) identified only by Proteome Discoverer, 9 proteins only by MaxQuant analysis, and 5 proteins (Cadherin-1 (CDH1), EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1), Prostate-specific antigen (PSA) (KLK3), Secreted and transmembrane protein 1 (SECTM1), and Transthyretin (TTR)) discovered by both software. This evidence concerns the gene EFEMP1 and posterior cortical atrophy.