However, the proteins identified by the MaxQuant software alone seem to provide a discrimination between PCa patients and non-cancer subjects based on two protein clusters, depicted in the heatmap: AZGP1(zinc-alpha-2-glycoprotein)-SPP1 (Osteopontin); CD14 (Monocyte differentiation antigen CD14)-MASP2 (Mannan-binding lectin serine protease 2) (Figure 1B). Here, SPP1 is linked to posterior cortical atrophy.