The analysis of proteogenome data revealed 6 differentially abundant mutant protein isoforms in PCa patients compared with cancer-free individuals, namely Protein AMBP (AMBP*A286G), Sodium/hydrogen exchanger 9B1 (SLC9B1*N70S), Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2*Q1062H), Zinc finger protein 624 (ZNF624*S207F), Vasorin (VASN*R161Q), and Complement decay-accelerating factor (CD55*S162L) (Table S4, Figure S2). The gene discussed is HSPG2; the disease is cancer.