In contrast, TCR-T treatment had no significant effect on the growth of MelA375_PD-L1 tumors compared to injection of untransduced (UT) Tßcells, and all mice had to be sacrificed between four and seven weeks (Figure 1E,F), indicating that a very potent PRAME-TCR was not sufficient to control growth in this very challenging PD-L1-positive tumor model. Here, CD274 is linked to neoplasm.