Following demographic and clinical variables were associated with a significantly higher risk of death: anatomical location in esophagogastric junction (EGJ) (mOS: 11 vs. 87 months; HR = 4.70; p = 0.0040), lymph node metastases (N1-N3b) (mOS: 29 months vs. NR; HR = 4.43; p < 0.0001), grade G3 (mOS: 33 months vs. NR; HR = 2.77; p = 0.0038) and no pathological tumour response to NAC (TRG3, TRG4) (mOS: 35 months vs. NR; HR = 6.42; p = 0.0003). The gene discussed is NXN; the disease is neoplasm.