Multivariate analysis confirmed the independent, unfavourable prognostic value of anatomical location (EGJ) (HR = 6.63; p = 0.0042), positive lymph nodes (HR = 3.94; p = 0.0009), grade G3 (HR = 2.66; p = 0.0304) and no pathological tumour response to NAC (TRG3, TRG4; HR = 5.92, p = 0.0066). This evidence concerns the gene NXN and neoplasm.