Nine peptides were detected in higher levels in urine from PCa patients; these included fragments of matrix metalloproteinase-2 (MMP2, 4.8× higher), three peptide fragments of fibrinogen alpha chain (FGA, 3.2–5.6×), and Histone H1.4 (HIST1H1E, 7.1×). Here, MMP2 is linked to posterior cortical atrophy.