When we examined the distribution of patients for each model’s risk score, we found that the SoC model was able to discriminate the ‘No Cancer’ from the highest risk patients (Gs ≥ 4 + 3) with good accuracy but could not separate Gs3 + 3 from clinically significant Gs3 + 4 disease, with the latter possessing a lower mean SoC risk score (Figure 1A). The gene discussed is DNAJC21; the disease is cancer.