Although the roles of SRSF6 in AS are less extensively studied than those of other SR proteins, such as SRSF1 and SRSF2, SRSF6 has shown its activity in the regulation of global AS events in colorectal cancer, human pancreatic β-cells, and numerous individual AS events, such as CD45, calcitonin/CGRP, FGFR1, Tau, CD44, HIV-1 vpr, Bim, SMN2, Bcl-x, and huntingtin [9,10,11,13,14,16,17,18,26,27,55]. The gene discussed is SRSF1; the disease is colorectal cancer.