Regarding acute lymphoblastic leukemia, although the series included in the validation was small, the validation has once again revealed the possibility of integrating the detection of point mutations, fusions, and CNVs of both single gene (IKZF1) or certain locus (CDKN2A/B) and large chromosomal aberrations (ploidy). This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.