In the 15 samples with a diagnosis of chronic myeloid leukemia provided by the hospitals, we identified fusions involving the ABL1 gene but, in addition to the BCR-ABL rearrangements, we also detected mutations in regulatory genes (CBL, TET2, EZH2 and ASXL1), RAS signaling genes (NRAS, KRAS), as well as genes involved in RNA splicing (SF3B1, SRSF2) (File S2). This evidence concerns the gene EZH2 and chronic myelogenous leukemia, BCR-ABL1 positive.