We next addressed the question of the possible function of SRPX upregulation in glioblastomas and found that siRNA depletion of the SRPX mRNA significantly reduced the cell viability and colony formation of glioblastoma cells, whereas SRPX depletion did not affect the cell viability of HEK293T cells that served as control, suggesting a specific role of SRPX in glioblastoma tumorigenesis. Here, SRPX is linked to glioblastoma.