The median circulating GDF-15 concentration was elevated in the uterine sarcoma group and was (943 ng/L) in contrast to the myoma uteri group, where it was (647 ng/L).Its level was significantly higher in patients with metastatic disease, with large tumor diameter, and with leiomyosarcomas as compared with other histological types. The gene discussed is GDF15; the disease is leiomyosarcoma.