SEMA7A and glioblastoma: Interestingly, SEMA7A, a member of the semaphorin family of guidance cues [49], was found on the surface of GBM stem cell-derived exosomes; notably, by interacting with integrin β1 receptor, this signal activated focal adhesion kinase into glioblastoma stem cells, enhancing their motility and tumor aggressiveness [50].