Transient transfection of MM cell lines with anti-MALAT1 short hairpin RNAs (shRNAs) halts cell cycle in G1 phase, induces apoptosis by modulating the pro-apoptotic Bax and the anti-apoptotic Bcl-2 proteins in vitro, and reduces tumor growth in xenografted mice [33]. This evidence concerns the gene MALAT1 and Miyoshi myopathy.