Focusing on MTC vs. NT genes (Figure 4B and Table S1), among the top downregulated genes we found that genes related to thyroid function (such as TG, FOXE1, SLC26A4, TSHR, TPO, GLIS3, DUOX1, DUOX2, PAX8, and DIO2) were highly expressed in the NTs, as expected [49]. This evidence concerns the gene DUOX1 and medullary thyroid gland carcinoma.