SOX2 and neoplasm: For these studies, we used five engineered i-SOX2 tumor cell lines, which included two medulloblastoma cell lines (i-SOX2-ONS76, i-SOX2-UW228), two prostate tumor cell lines (i-SOX2-DU145, i-SOX2-LNCaP), and one colorectal cell line (i-SOX2-HCT116).