Changes in nuclear proteins induce malformation in cell division, migration, signaling, and gene expression, such as the overexpression of lamin A. This stimulates the reconstruction of the cytoskeleton via the upregulation of actin-binding protein plastin-3 and downregulation of E-cadherin in colon cancer cells (CCCs), thus resulting in the increase of migration and invasiveness of cancer cells [44]. Here, CDH1 is linked to malignant colon neoplasm.