For example, while an MGMT promoter unmethylated isocitrate dehydrogenase (IDH) wild type (WT) GBM patient is likely to succumb to the disease within a year, patients with an IDH-mutated, highly MGMT promoter methylated tumour have a fair chance at living beyond 5 years [11]. The gene discussed is MGMT; the disease is glioblastoma.