CD274 and neoplasm: High co-expression was detected in a substantial number of patients; i.e., CD44v6 high (>30% positive tumors cells) combined with integrin α2β1 high (>80% positive tumor cells) in 11 out of 52 (21.15%) patients, CD44v6 high combined with Hsp90 high (>70% positive tumor cells) in 14 out of 52 (26.92%) patients and CD44v6 high combined with PD-L1 high (>1% positive cells) in 12 out of 52 (23.1%) patients.