ESR1 and uterine corpus sarcoma: Indeed, in recent years, the peculiarity of uLMS compared to extra-uterine sarcomas has been well defined based on the TCGA study [14,15,16,17,18,19]: uLMS are characterized by a higher level of hypomethylated estrogen receptor-dependent target genes, as well as DNA damage response scores, and genomic instability compared to extra-pelvic sarcomas [18].