For example, the NCT03337698 study is a Phase Ib/II multicenter, randomized, large cohort study of 435 stage IV NSCLC patients, designed to evaluate the efficacy and safety of multiple immunotherapy-based treatment combinations, testing atezolizumab with 14 different molecules, including the A2AR antagonist CPI-444. Here, ADORA2A is linked to non-small cell lung carcinoma.