In patients with NSCLC, CD73 is expressed on cancer cells, cancer-associated fibroblasts (CAFs), and tumor-infiltrating lymphocytes (TILs), and its expression correlates with the expression of hypoxia- inducible factor-1, a trend confirmed in in vitro studies using the lung cancer cell lines H1299 and A549 [36]. The gene discussed is NT5E; the disease is non-small cell lung carcinoma.