Indeed, thanks to in silico analyses, we have shown that the molecular pattern of the “purinergic genes”, namely P2RX7, NT5E (CD73), ENTPD1 (CD39), ADORA2A, ADORA2B, and ADORA3, is very heterogeneous in both the 135 NSCLC cell lines and the 995 NSCLC patients available in the cBio Cancer Genomic Portal [85,86] (unpublished results). This evidence concerns the gene NT5E and non-small cell lung carcinoma.