In HCC patients, exome sequences revealed cooperating mutations of CTNNB1 with AT-Rich Interaction Domain 2 (ARID2), NFE2 Like BZIP Transcription Factor 2 (NFE2L2), TERT, Apolipoprotein B (APOB) and Lysine Methyltransferase 2D (MLL2). This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.