PFKFB3 and neoplasm: We demonstrate that a 31-nt tRNAiMet fragment (tRiMetF31) derived from miR-34a-guided cleavage may function as a tumor suppressor to inhibit cell proliferation and angiogenesis through directly targeting PFKFB3, providing novel insight into the suppressive role of the miR-34a tumor suppressor network in neuroblastoma progression.