PFKFB3 and familial pancreatic carcinoma: The elevated expression of PFKFB3 was reported in numerous human malignancies, including HER2+ breast cancer [51], head and neck squamous cell carcinoma [52], hepatocellular carcinoma [53], colon carcinoma [54], neuroblastoma [55], and pancreatic cancer [56], correlated with poor prognosis.