A role for GPC3 in the cancerogenesis of HCC has been described in reference to its ability to promote epithelial-to-mesenchymal transition via ERK signaling and to stimulate cell proliferation through enhancing oncogenetic pathways such as the Wnt/Frizzled and IGF signaling axis [111,112,113]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.