Biglycan belongs to the small leucine-rich proteoglycans (SLRP) family and may have a relevant role in HCC progression as it can interact with surface receptors such as toll-like receptors (TLRs) 2 and 4, CD14, and CD44, which in turn influence processes such as production of inflammatory cytokines (especially in macrophages), autophagy, angiogenesis, cell growth, and migration, to eventually promote tumor progression or suppression [122,123]. This evidence concerns the gene CD44 and hepatocellular carcinoma.