TGFB1 and neoplasm: The anti-tumor and anti-angiogenic functions of this proteoglycan can be attributable to its capacity to bind to several growth factors and receptors (including the already mentioned TGFβ, PDGF, activin C, CTGF, EGFR, c-Met, IGF-IR, VEGFR2, TLR2, and TLR4), thus promoting their degradation or inactivating their downstream signaling activity.