EP300 and hepatocellular carcinoma: For example, a shed form of syndecan 1 (sSDC1), released by cancer cells, can be harvested from extracellular medium by bone marrow-derived stromal cells and conveyed into the nucleus where it binds to and inhibits the function of histone acetyl transferase p300 [9]; moreover, heparan sulfates were found to prevent transcription factors, such as AP-1, SP-1, ETS-1, and nuclear factor κB, from interacting with their consensus DNA sequences in HepG2 cells of hepatocellular carcinoma (HCC) [10].