In particular, determining the HER2-HER3 dimerization status of FFPE tumor tissue using FRET-FLIM (Förster resonance energy transfer-Fluorescence Lifetime Imaging Microscopy) has been shown to predict the likelihood of metastatic relapse up to 10 years after surgery independently of tumor HER2 expression [8]. The gene discussed is ERBB3; the disease is neoplasm.