Pioneering studies evaluating the potential of [68Ga]Ga-PSMA-11 PET to detect intraprostatic tumour foci have documented proportionality between the intensity of the PSMA tumour uptake and ISUP grade group, the size of tumor foci, tumor growth pattern (infiltrative versus expansive), serum PSA, and higher D’Amico scores [23,24,25,26,27,28,29,30,31,32]. This evidence concerns the gene FOLH1 and neoplasm.