Surprisingly, we found a downregulation rather than an upregulation of several Src kinase and Src kinase-related family members—i.e., B-lymphoid tyrosine kinase (BLK), lymphocyte-specific protein tyrosine kinase (LCK) and Fyn-related kinase (FRK)—in the AKT/mTOR-inhibitor-resistant tumor cells. The gene discussed is AKT1; the disease is neoplasm.