SORT1 and ovarian carcinoma: To first confirm the requirement of SORT1 for peptide internalization, siRNA-mediated silencing of SORT1 was performed in ES-2 and SKOV3 ovarian cancer cells and TH19P01-Alexa488 uptake found significantly decreased by 58% and 67%, respectively (Figure 4A; Figure S6 in the Supplementary Materials Section).