In this setting, we can also include AML with minimal differentiation, which is diagnosed when blasts are positive for at least two myeloid-associated antigens (usually CD117 and CD13), do not express MPO at cytochemistry (even though some blasts might be positive at flow cytometry and immunohistochemistry), and might express CD7 and CD2 antigens (roughly 40% of cases) [4]. Here, MPO is linked to acute myeloid leukemia.