A diagnosis of ETP-ALL is based on the expression of cytoplasmic CD3, CD7, and CD2, with a lack of CD1a and CD8, and positivity for one or more of the myeloid/stem cell markers CD34, CD117, HLADR, CD13, CD33, CD11b, or CD65 [5,21]. Here, CD8A is linked to acute lymphoblastic leukemia.