The complex interrelationship between AMBN, ceRNA (LINC02701–hsa-miR–GFAP) and MSX2 may be another reason for the interesting phenomenon that the expression level of AMBN is lower in advanced TGCT than in earlier stages, but high levels of AMBN in cancer tissue predict a shorter time to recurrence after first cure. The gene discussed is AMBN; the disease is cancer.