These cytokines are known to exert proliferative activities directly on tumor cells, but also immunosuppressive functions (IL-6, IL-10) [72,73], as well as paraneoplastic inflammatory activities, referred to as KSHV-associated inflammatory cytokine syndrome (KICS), with very high circulating levels of IL-6 and IL-10 [74,75,76]. The gene discussed is IL10; the disease is neoplasm.