[125] Alterations in the ultrastructure of histones in chromatin remodellers, such as p300, HDACs, and PBRM1, are altered in patients with pancreatic adenocarcinoma, which lead to the aberrant expression of c-MYC and KRAS, which act as oncogenes stimulating the proliferation of tumour cells in pancreatic adenocarcinoma. The gene discussed is PBRM1; the disease is pancreatic adenocarcinoma.