EP300 and neoplasm: The mechanism by which different microRNAs stimulate tissue invasion and metastasis are widely described as miRNA 218-, miR-155-, and miRNA-10-stimulating epidermal growth factors, TGF-β, metalloproteinases, and endothelial growth factors and the inhibition of metastasis suppressor genes, such as EP300, and they act together to promote the vascular invasion of tumour cells [100,101].