As a result, crucial changes in the 2020 European Association of Urology (EAU) guidelines were established, promoting mpMRI, firstly to being recommended for every patient with PCa suspicion (elevated PSA/abnormal DRE) before performing the biopsy, and secondly, as a tool to detect csPCa in the active surveillance (AS) [18]. This evidence concerns the gene KLK3 and posterior cortical atrophy.