Using (targeted) DNA (t)NGS technologies, from now on referred to as NGS, multiple studies identified the involvement of various intracellular signaling cascades (f.e., apoptosis, DNA damage response, JAK/STAT, MAPK, NF-κB, NOTCH, PI3K) in DLBCL lymphomagenesis. Here, NFKB1 is linked to diffuse large B-cell lymphoma.