We are currently investigating the impact of short duration immunomodulating therapies to improve the tumor microenvironment (chemokine modulation consisting of interferon-alpha, TLR3 agonist, and COX-2 inhibitor), given along with standard chemotherapy in the neoadjuvant setting in early TNBC in a phase 1 clinical trial (NCT04081389), which may help us avoid giving immune therapies for an extended duration, especially after surgery in the adjuvant setting [75,76,77]. This evidence concerns the gene TLR3 and neoplasm.