In the context of cancer, Dectin-1 targeting using free ꞵglucans [258,259,260] and ꞵglucan-coated gold nanoparticles carrying a MUC4-TF peptide [261] induces strong humoral responses, demonstrated by the presence of high titres of specific antibodies and antigen-recognizing T cells [261]. The gene discussed is CLEC7A; the disease is cancer.