On the other hand, an upregulation of GalNAc2,6-sialyltransferase (ST6GalNAc-I) in tumours results in the overexpression of sTn, (NeuAc2,6-GalNAc-Ser/Thr) preventing further O-glycan elongation. The gene discussed is EEF1A2; the disease is neoplasm.