Mannose-rich glycan structures conjugated to liposomes [236,237], polyamidoamine dendrimers [238] or polylactide-co-glycolide (PLGA) based nanoparticles [239], results in increased IL-12 with IgG antibodies, enhanced CD4+ T and CD8+ T cells and protection against tumour upon immunisation [240]. The gene discussed is CD8A; the disease is neoplasm.