Next, AAV patients were divided into four groups according to the results of the ACPA and ANCA detection: 11, 4, 124, and 29 patients were assigned to the ACPA-positive ANCA-positive, ACPA-positive ANCA-negative, ACPA-negative ANCA-positive, and ACPA-negative ANCA-negative groups, respectively. The gene discussed is PRTN3; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.