MMP8 and periodontitis: An Italian team of researchers validated the efficiency of the matrix metalloproteinase-8 (MMP-8) chair-side test; the presence of MMP-8 in the oral cavity correlates with the progression and severity of periodontitis-related clinical parameters, i.e., an increase in gingival bleeding, loss of gingival attachment, and increased depth of the periodontal pockets [27,28].