YAP1 and neoplasm: Furthermore, although the main function of miR-375 has not been characterized, a ZEB1-miR-375-YAP1 signaling pathway has been identified to regulate epithelial plasticity in PCa by Selth et al., who also discovered that miR-375 was highly and positively associated with tumor cells in the metastatic-stage PCa, thus bringing insight into tumor cell invasion mechanisms of PCa in relationship with miR-375 expression [13].