Additional noteworthy contributions to this field include the work of Pasquini et al., who used a 2D CNN on 6 different MRI modalities to discriminate between the IDH status of GBM patients with the best performance obtained on relative cerebral volume (rCBV) sequences (Accuracy = 83%), implying the underlining IDH pathophysiology [27]. This evidence concerns the gene IDH2 and glioblastoma.