In this meta-analysis, we investigated the effect of three variants (namely the PRDM16 rs2651899, the rs10166942 near the TRPM8 gene, and the LPR1 rs11172113) on the risk of migraine, as well as on the risk of the main migraine phenotypes, namely the MA and the MO. This evidence concerns the gene PRDM16 and migraine disorder.